The natural disaster measured 7.4 and shook buildings on the streets of Mexico City, where thousands of people poured onto the streets.
A woman is carried on a stretcher after being pulled from the debris of a collapsed building in Mexico City on Tuesday.
The latest natural disaster comes 11 days after a huge temblor killed 96 people.
The damage from the temblor was not immediately clear, but its jolt was felt far. Visit MarketWatch.com for more information on this news.
The 1985 Mexico City natural disaster killed 5,000 people and caused serious damage to the Greater Mexico City area. The AP reported it is unclear if there were people inside. "We're going to go to a building that fell to see if we can help". Its epicenter was in the state of Puebla, about 80 miles southeast of the capital, Mexico City.
A bulldozer removes debris from a partially collapsed building after an quake in Mexico City, Tuesday, Sept. 19, 2017.
The US Geological Survey said the natural disaster was 7.1 magnitude, hitting 5 miles (8km) southeast of Atencingo in the state of Puebla at a depth of 32 miles (51km).
"We ran outside thinking all was going to collapse around us", said Lazaro Frutis, a 45-year-old who escaped an office building before it crumpled to the ground.
"People are really scared right now", said dentist Claudia Meneses who was in her clinic in Mexico City's Lindavista neighborhood when the quake struck mid-afternoon.
It's the second major quake the city has experienced this month, after a magnitude 8.1 natural disaster struck off the coast of Mexico on September 8.