Despite regaining the number one status earlier this year, Kerber has struggled for form recently, losing early in Madrid and Rome.
"I will probably enjoy it much more than the other years", she added. The motivation I had today was incredible - and I really just didn't want to lose.
Makarovas take when informed of the history made by her victory?
"I was also fighting with my emotions not to wait for a mistake (by Kerber)", she said courtside.
Although maybe not, considering how Kerber has fared lately.
Williams, seeded 10, has played every year since 1997 with the exception of 2011 and despite her senior citizen status, she is still a contender at the Slams as her run to the Australian Open final in January proved.
Mattek-Sands, the world number 117, will now lock horns with 2010 Roland Garros finalist Sam Stosur of Australia to book her place in the third round.
"On clay I'm really not feeling so good, especially on my movement, because, I don't know, I can not slide so good". Its kind of I dont want to say open, because everyones really good, but very competitive, Rogers said, and theres not like that dominating force..
Anisimova, ranked 267, won the first set but Nara fought back to win 3-6 7-5 6-4.
Makarova converted on six of 14 break point attempts and had 19 unforced errors to Kerber's 25.
The American then came from 3-0 down to win the breaker, a thumping backhand return victor earning a set point that was converted with an unreturned serve, but left the court for treatment after moving ahead. But that was about it. Two-time Wimbledon champion Kvitova downed outclassed Julia Boserup of the United States 6-3, 6-2, falling to her knees in celebration in the moment of victory before weeping at the net.
"Yesterday I was thinking how everything will be and I couldn't really imagine", she said.
Halep is one of the best players in the WTA circuit, but what surprises most of her fans is her cabinet of trophies, which does not include a grand slam title.
Although Kvitova said her hand felt "a little bit tricky" at times, particularly on the serve, she never experienced pain during the match. Gave her a big hug. (Czech for "Come on!") emblazoned on black t-shirts worn by her entourage, who she pointed to afterwards.
Russia's Ekaterina Makarova celebrates winning in two sets 6-2, 6-2, against Germany's Angelique Kerber at the French Open tennis tournament at the Roland Garros stadium in Paris, France, Sunday, May 28, 2017.