The match kicks-off at 8:45pm.
This will be the 11th time in the European Cup/Champions League that Bayern Munich plays Real Madrid in the knockout round, and it could be one of the fiercest matches yet.
What's at stake: A chance to get a nice advantage after the first leg. Bayern will look to win while not concede, while Real's plan will be to get a couple away goals and head back to the Iberian Peninsula with confidence and momentum.
Ancelotti says "little things will make the difference" between the star-studded squads that will see two goal-scoring giants go head-to-head. Real have broken the world record transfer fee on five consecutive occasions through the years in signing Luis Figo, Zinedine Zidane, Kaka, Cristiano Ronaldo and Gareth Bale, who moved to the Bernabeu for £86million in 2013.
Between the matches against the German side and Spanish rivals Barcelona, he is also expected to play against Sporting Gijon, a crucial match as Real seek to win their first Spanish league title since 2011-12.
"It is hard, they are one of the best teams in the world, with world-class players", the Dutch winger told AS.
This comes, according to MARCA, due to the 4-0 thrashing Real Madrid gave Bayern at the Allianz in 2014. "This tie could easily be the Champions League final", Kroos said.
The Germany global joined the Bundesliga giants at the age of 16 and played over 200 matches, before leaving the club in 2014.
"Whether Lewandowski plays or not won't affect our strategy or our confidence for the game".
Both teams will take to the field without their main central defenders.
The former suffered a double rib fracture in Saturday's 1-1 draw with Atletico Madrid, while the latter is out for a month with a hamstring injury.
Vidal could have finished with a first-half hat-trick when he stepped up to take a penalty after Dani Carvajal's handball from a Franck Ribery shot.
Bayern Munich goalkeeper Manuel Neuer returned to training on Monday, increasing the likelihood of him playing against Real Madrid on Wednesday.
"We're very confident. It's a European cracker featuring two top teams", said Mueller.